April 2023

The discovery of DNA’s double helix structure 70 years ago opened up a world of new science — and also sparked disputes over who contributed what and who deserves credit.

Much of the controversy comes from a central idea: that James Watson and Francis Crick — the first to figure out DNA’s shape — stole data from a scientist named Rosalind Franklin.

Now, two historians are suggesting that while parts of that story are accurate — Watson and Crick did rely on research from Franklin and her lab without permission — Franklin was more a collaborator than just a victim.

In an opinion article published Tuesday in the journal Nature, the historians say the two different research teams were working in parallel toward solving the DNA puzzle and knew more about what the other team was doing than is widely believed.

“It’s much less dramatic,” said article author Matthew Cobb, a zoologist at the University of Manchester who is working on a biography of Crick. “It’s not a heist movie.”

Photograph 51

The story dates back to the 1950s, when scientists were still working out how DNA’s pieces fit together.

Watson and Crick were working on modeling DNA’s shape at Cambridge University. Meanwhile, Franklin — an expert in X-ray imaging — was studying the molecules at King’s College in London, along with a scientist named Maurice Wilkins.

It was there that Franklin captured the iconic Photograph 51, an X-ray image showing DNA’s crisscross shape.

Then, the story gets tricky. In the version that’s often told, Watson was able to look at Photograph 51 during a visit to Franklin’s lab. According to the story, Franklin hadn’t solved the structure, even months after making the image. But when Watson saw it, “he suddenly, instantly knew that it was a helix,” said author Nathaniel Comfort, a historian of medicine at Johns Hopkins University who is writing a biography of Watson.

At about the same time, the story goes, Crick also obtained a lab report that included Franklin’s data and used it without her consent.

And according to this story, these two “eureka moments” — both based on Franklin’s work — Watson and Crick “were able to go and solve the double helix in a few days,” Comfort said.

This “lore” came in part from Watson himself in his book “The Double Helix,” the historians say. But they suggest this was a “literary device” to make the story more exciting and understandable to lay readers.

After digging in Franklin’s archives, the historians found new details that they say challenge this simplistic narrative — and suggest that Franklin contributed more than just one photograph along the way.

The proof? A draft of a Time magazine article from the time, written “in consultation with Franklin” but never published, described the work on DNA’s structure as a joint effort between the two groups. And a letter from one of Franklin’s colleagues suggested Franklin knew her research was being shared with Crick, the authors said.

Taken together, this material suggests the four researchers were equal collaborators in the work, Comfort said. While there may have been tensions, the scientists were sharing their findings more openly — not snatching them in secret.

“She deserves to be remembered not as the victim of the double helix, but as an equal contributor to the solution of the structure,” the authors conclude.

Howard Markel, a historian of medicine at the University of Michigan, said he’s not convinced by the updated story.

Markel — who wrote a book about the double helix discovery — believes that Franklin got “ripped off” by the others and they cut her out in part because she was a Jewish woman in a male-dominated field.

Franklin’s work critical 

In the end, Franklin left her DNA work behind and went on to make other important discoveries in virus research, before dying of cancer at age 37. Four years later, Watson, Crick and Wilkins received a Nobel prize for their work on DNA’s structure.

Franklin wasn’t included in that honor. Posthumous Nobel prizes have always been extremely rare, and now aren’t allowed.

What exactly happened, and in what order, will likely never be known for sure. Crick and Wilkins both died in 2004. Watson, 95, could not be reached, and Cold Spring Harbor Laboratory, where he served as director, declined to comment on the paper.

But researchers agree Franklin’s work was critical for helping unravel DNA’s double helix shape — no matter how the story unfolded.

“How should she be remembered?” asked Markel. “As a great scientist who was an equal contributor to the process. It should be called the Watson-Crick-Franklin model.”
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Water may be more widespread and recent on Mars than previously thought, based on observations of Martian sand dunes by China’s rover. 

The finding highlights new, potentially fertile areas in the warmer regions of Mars where conditions might be suitable for life to exist, though more study is needed. 

Friday’s news came days after mission leaders acknowledged that the Zhurong rover had yet to wake up since going into hibernation for the Martian winter nearly a year ago. 

Its solar panels are likely covered with dust, choking off its power source and possibly preventing the rover from operating again, said Zhang Rongqiao, the mission’s chief designer. 

Before Zhurong fell silent, it observed salt-rich dunes with cracks and crusts, which researchers said likely were mixed with melting morning frost or snow as recently as a few hundred thousand years ago. 

Their estimated date range for when the cracks and other dune features formed in Mars’ Utopia Planitia — a vast plain in the northern hemisphere — is sometime after 1.4 million to 400,000 years ago or even younger. 

Conditions during that period were similar to what they are now on Mars, with rivers and lakes dried up and no longer flowing as they did billions of years earlier. 

Studying the structure and chemical makeup of these dunes can provide insights into “the possibility of water activity” during this period, the Beijing-based team wrote in a study published in Science Advances. 

“We think it could be a small amount … no more than a film of water on the surface,” co-author Xiaoguang Qin of the Institute of Geology and Geophysics said in an email. 

The rover did not directly detect any water in the form of frost or ice. But Qin said computer simulations and observations by other spacecraft at Mars indicated that even nowadays at certain times of year, conditions could be suitable for water to appear. 

What’s notable about the study is how young the dunes are, said planetary scientist Frederic Schmidt at the University of Paris-Saclay, who was not part of the study. 

“This is clearly a new piece of science for this region,” he said in an email. 

Small pockets of water from thawing frost or snow, mixed with salt, likely resulted in the small cracks, hard crusty surfaces, loose particles and other dune features like depressions and ridges, the Chinese scientists said. They ruled out wind as a cause, as well as frost made of carbon dioxide, which makes up the bulk of Mars’ atmosphere. 

Martian frost has been observed since NASA’s 1970s Viking missions, but these light dustings of morning frost were thought to occur in certain locations under specific conditions. 

The rover has now provided “evidence that there may be a wider distribution of this process on Mars than previously identified,” said Trinity College Dublin’s Mary Bourke, an expert in Mars geology. 

However small this watery niche is, it could be important for identifying habitable environments, she added. 

Launched in 2020, the six-wheeled Zhurong — named after a fire god in Chinese mythology — arrived at Mars in 2021 and spent a year roaming around before going into hibernation last May. The rover operated longer than intended, traveling nearly 2,000 meters.
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The world record for the least sleep in a day among mammals goes to elephant seals, according to new research.
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Snake experts in South Africa say an energy crisis is partly to blame for a shortage of antivenom in sub-Saharan Africa that has left at least three people dead in the past three weeks. South Africa supplies antivenom to the region, but frequent power cuts have made it harder to store the refrigerated supplies. Vicky Stark reports from Cape Town, South Africa.
Camera: Shadley Lombard 
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